Can Taking Medicines at Wrong Time of The Day be Harmful
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According to the University of Colorado School of Medicine research, taking medicines at the wrong time of the day can be harmful. 

A study published by the University of Colorado School of Medicine has revealed that chronotherapy may increase drug efficacy in patients. Tobias Eckle, a researcher for the school, has been studying how circadian rhythms can impact (and perhaps improve) how a human body responds to treatment.

According to Eckle 50 of the most commonly used medicines in the USA have directions that suggest they need to be taken at a specific time of the day. There are two main reasons why doctors don’t direct patients to take them at specific times. 

He explained in an article for The Conversation, many physicians are not aware that some drugs work better during a specific time of the day. While the other reason being most drugs have not been studied for possible different effects during a 24-hour cycle. Some patients may be required to take medications in the morning or evening, as they might not remember since they’re often busy.

A 2019 study came up with some interesting conclusions about a few relationships between drug efficacy and circadian rhythms. One detail from the study, for example, was that certain breast cancer drugs should be administered in the morning in order to maximize efficacy.

Yet another compelling study has explored whether taking NSAIDs, like common painkillers, could negatively affect bone healing. The study found that if taken late in the evening, over-the-counter pain medicines can slow the rate of bone healing.

In his latest study, Eckle focuses on a common preoperative sedative called midazolam. Earlier research had found that administration of midazolam led to a reduced expression of a key circadian rhythm protein that protects the heart from damage. So, Eckle and colleagues looked at nearly two million health records to see if rates of postoperative heart complications in patients receiving midazolam differed depending on the time of day surgery was performed.

Eckle added, “We performed a large dataset analysis and demonstrated that administering midazolam is associated with an increased risk of myocardial injury in non-cardiac surgery when surgeries occurred at night and in healthier patients. That suggests midazolam interferes with the circadian system in humans.”

The analysis discovered that surgical procedures are safer during the day than at night. Out of healthy patients, those who received midazolam during night surgery were three times more likely to suffer damage to their hearts.

A deeper understanding of this specific relationship between the time of day (circadian rhythm) and midazolam is needed to determine whether the findings from Eckle are significant. It may be challenging to retroactively establish optimal times to administer the hundreds of drugs currently being used, but a study in new medicines should take circadian rhythms into account.

Eckle concluded by saying, “Drugs are often administered according to what’s most efficient. But what is most efficient, may in the end cause damage.”

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